Kaha Kū.
Ka mea kākau moʻolelo
- 1 Charleston Alcohol Research Center, Keʻena ʻo Psychiatry a me Neuroscience, Ke Kulanui Lapaʻau o South Carolina & VAMC, Charleston, SC 29425.
- 2 Charleston Alcohol Research Center, Department of Psychiatry and Neuroscience, Medical University of South Carolina & VAMC, Charleston, SC 29425. Electronic address: [pale ʻia ka leka uila].
Hōʻuluʻulu Manaʻo
Hoʻokomo pū ka neuropeptide oxytocin (OXT) i nā hana hoʻoikaika i pili i nā kaʻina hana, ka hoʻomanawanui, ka hoʻomanaʻo a me ke kaumaha. Ma o nā launa pū me ka uku o ka lolo a me nā ʻōnaehana kaumaha, ʻike ʻia ka OXT e hana i ka nui o nā maʻi neuropsychiatric, he mea nui ka poʻe i komo i ka hoʻohui ʻana o ka piliona, e like me ka waiʻona a me ka mea inu wai (Heilig et al., 2016). E like me, ke ulu nei ka makemake i ka pūnaehana ʻo oxytocin e hiki ai i ka hopena therapeutic target no ka mālama ʻana i ka waiʻona a me nā mea hoʻohana pono. Ka hoʻopiʻi ʻana i nā hōʻike preclinical hōʻike i ke alakaʻi ʻana o ka OXT i ka hoʻomohala ʻana i ka hoʻomaloka ʻana, ka hoʻohaʻahaʻa ʻana a me ka hoʻihoʻi ʻana i nā hōʻailona, a hoʻohālikelike i ka nui o ka ʻakaʻawa / wai-ʻimi ʻana a me nā mea inu wai. Eia kekahi, aia kekahi mau hōʻike e hōʻike ana e hiki ke kōkua ʻo OXT i ka hoʻohuli ʻana i nā neuroadaptations e kū nei ma muli o ka hopena o ka waiʻona a i ʻole ka mea i ke kolohe. I kēia manawa, aia wale nō nā mea noiʻi o nā lāʻau lapaʻau i mālama ʻia i ka wai ʻona a me nā mea pili ʻana i ka lāʻau lapaʻau. Hoʻopau kēia hōʻike i nā puke kūloko a me nā lapaʻau ma luna o nā hopena o ka hoʻokele OXT i ka waiʻona o ka waiʻona a me ka pono lāʻau. Eia kekahi, ke kamaʻilio pū nei mākou i nā mea pili OXT me ka hypothalamic-pituitary-adrenal axis a me nā ʻōnaehana neurotransmitter maromaro i loko o kahi addiction circuitry.