Comment: Male rats allowed to copulate until reaching sexual exhaustion exhibit a long-lasting sexual behavior inhibition (around 72h) that can be reversed by systemic opioid receptor antagonist administration. Copulation activates the mesolimbic dopaminergic system (MLS) and promotes endogenous opioid release. In addition, endogenous opioids, acting at the ventral tegmental area (VTA), modulate the activity of the MLS….[Intra-VTA] Naltrexone reversed the sexual inhibition of sexually exhausted rats, evidenced by an increased percentage of animals capable of showing two successive ejaculations. [But] Intra-VTA naltrexone infusion to sexually experienced male rats had an inhibitory effect on sexual activity. The opposite effects of intra-VTA naltrexone on male rat sexual behavior expression of sexually experienced and sexually exhausted rats is discussed.
Behav Res apparet ingenium.
2013 Nov 1: 256: 64, 71. doi: 10.1016 / j.bbr.2013.07.056.
Garduño-Gutiérrez R, León-Olea M, Rodríguez-Manzo G.
Source: Departamento de Farmacobiología, Cinvestav Sede Sur, Calzada de los Tenorios 235, Col. Granjas Coapa, Delegación Tlalpan, C.P. 14330, México D.F., Mexico; Departamento de Neuromorfología Funcional, Dirección de Neurociencias, Instituto Nacional de Psiquiatría “Ramón de la Fuente Muñiz”, Av. México-Xochimilco 101, Col. San Lorenzo Huipulco, C.P. 14370, México, D.F., Mexico.
Abstract
Masculum mures inclusi essent liceat pecore coierit eo ad lassitudinem corpo revelabis turpitudinem properabant inhibicionis ostendit DIUTURNUS (circa 72h) qui auderet contradicere systemica receptor administratione mortem occupavi. Cuiusconceptionem sequitur copulam mesolimbic dopaminergicae areae system (MLS) ac Favet opioid release endogenous. Praeterea endogenous opioids, agens de areae tegmentalis ventralis (VTA), flectentes est actio Suspendisse.
We hypothesized that endogenous opioids participate in the sexual exhaustion phenomenon by interacting with VTA opioid receptors and consequently, its reversal by opioid antagonists could be exerted at those receptors.
In hoc studium nos determinari quod bibitur de diversis infundatur aliqua rerum Effecta INTRA-VTA non-receptor propria cessit hosti naltrexone (0.1, 1.0μg / rat) in masculum mures inclusi essent prae lassitudine fugientes fornicatur inhibitionis supra dictum est per turpitudinem properabant. Ad evidentiam autem possibile efficiendum attinet, VTA opioid δ & receptores, in naltrexone mediata, revocatas liberalitates eius sexuali lassitudinem exercenda, ad alia bibitur in electionem selectivam effectus in δ-receptor Libano, naltrindole (0.03, 1.0μg / rat) sunt et probata.
Results showed that intra-VTA injection of 0.3μg naltrexone reversed the sexual inhibition of sexually exhausted rats, evidenced by an increased percentage of animals capable of showing two successive ejaculations. Intra-VTA infused naltrindole did not reverse sexual exhaustion at any dose. It is concluded that the MLS is involved in the reversal of sexual exhaustion induced by systemic naltrexone, and that μ-, but not δ-opioid receptors participate in this effect. Intra-VTA naltrexone infusion to sexually experienced male rats had an inhibitory effect on sexual activity. The opposite effects of intra-VTA naltrexone on male rat sexual behavior expression of sexually experienced and sexually exhausted rats is discussed.