Kodi zotsatira za opioid pambuyo pa pachimake mu ubongo ndi ziti?

Dongosolo lokhazikika la opioid lili ndi mabanja a 3 a peptides opioid, β-endorphin, enkephalins, ndi dynorphins, ndi zolandilira zawo. Ma peptides a opioid ndi zolandilira zawo zafalikira, koma zosankha, zogawa pakati ndi zotumphukira zamanjenje. Amapezeka makamaka m'mabwalo omwe amakhudzidwa ndi kusinthasintha kwa ululu, mphotho, kuyankha kupsinjika, komanso kudziwongolera.

Amakhulupirira kuti gulu limodzi la opioid (endorphins) limakhudzidwa makamaka ndi chisangalalo panthawi yogonana, pamene magulu awiri ena ali ndi udindo woletsa chilakolako chogonana ndi kumasulidwa kwa dopamine.

Maphunziro a nyama

Kutsegula kwa ma opioid receptors m'dera la medial preoptic kutsatira kuphatikizika kwa makoswe achimuna

Kuchuluka kwa zochitika zotulutsa umuna, khalidwe lopindulitsa lachilengedwe, limapangitsa kusiyana kwa mu ndi delta opioid receptor internalization mu rat's ventral tegmental area.

Endogenous opioid-induced neuroplasticity ya dopaminergic neurons mu ventral tegmental area imakhudza mphotho yachilengedwe ndi opiate.

Endogenous opioids amayimira kuletsa kugonana koma osati mankhwala osokoneza bongo omwe amachititsidwa ndi kukhutitsidwa ndi kugonana mu makoswe aamuna.

Umboni wa kusintha kwa ubongo wa enkephalin wokhudzana ndi kugonana kwa abambo

Kuphatikizidwa kwa ma endogenous opioidergic neurons pakusinthika kwa katulutsidwe ka prolactin poyankha makwerero mu khoswe lachikazi.

Njira ya IRS2-Akt mu midbrain dopamine neurons imayang'anira machitidwe ndi ma cellular ma opiates

Opiate-Induced Molecular and Cellular Plasticity of Ventral Tegmental Area ndi Locus Coeruleus Catecholamine Neurons

Opioid receptor ndi β-arrestin2 kachulukidwe ndi kusintha kogawa pambuyo pogonana mu gawo la ventral tegmental la makoswe achimuna.

Mesolimbic system imatenga nawo gawo pakubwezeretsanso kwa naltrexone kwa kutopa kwa kugonana: Zotsutsana ndi intra-VTA naltrexone administration pa kuphatikizika kwa makoswe achimuna odziwa kugonana komanso otopa pogonana.