Comment: It took 16 hours for hamster males to return to normal immune response.

1989 Sep;3(3):274-80.
Kress DW1, Ostrowski NL, McRae BL, Arora PK.

1 Section on Clinical Brain Imaging, National Institute of Mental Health, Bethesda, MD 20892.


The possibility that sexual behavior is associated with changes in natural killer cell activity was explored using a 4-h chromium-51 release assay. Mated male Golden Hamsters (Mesocricetus auratus) showed a significant suppression of natural killer cell activity 2 h after sexual activity relative to matched Virgin controls. Natural killer cell activity returned to control levels by 16 h postmating. The suppression of natural killer cell activity did not correlate with changes in plasma cortisol, transcortin, or testosterone levels, or with ejaculatory or intromissive behaviors. Administration of 0.40 mg/100 g of testosterone also suppressed natural killer activity at 2 h.