Endocannabinoids are brain chemicals similar to the psychoactive THC (tetrahydrocannabinol) component of marijuana. They have their own hedonic hotspot in nucleus accumbens shell, and it overlaps anatomically with the opioid hotspot.

Endocannabinoids are brain chemicals similar to the psychoactive THC (tetrahydrocannabinol) component of marijuana. They have their own hedonic hotspot in nucleus accumbens shell, and it overlaps anatomically with the opioid hotspot.