Endocannabinoids are brain chemicals similar to the psychoactive THC (tetrahydrocannabinol) component of marijuana. They have their own hedonic hotspot in nucleus accumbens shell, and it overlaps anatomically with the opioid hotspot.

Human

Masturbation to Orgasm Stimulates the Release of the Endocannabinoid 2-Arachidonoylglycerol in Humans